《An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria》 was written by Brennecke, Benjamin; Wang, Qinghua; Zhang, Qingyang; Hu, Hai-Yu; Nazare, Marc. Computed Properties of C5H11NO2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
Herein we report the development of a turn-on lanthanide luminescent probe for time-gated detection of nitroreductases (NTRs) in live bacteria. The probe is activated through NTR-induced formation of the sensitizing carbostyril antenna and resulting energy transfer to the lanthanide center. This novel NTR-responsive trigger is virtually non-fluorescent in its inactivated form and features a large signal increase upon activation. We show that the probe is capable of selectively sensing NTR in lysates as well as in live bacteria of the ESKAPE family which are clin. highly relevant multiresistant pathogens responsible for the majority of hospital infections. The results suggest that our probe could be used to develop diagnostic tools for bacterial infections. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Computed Properties of C5H11NO2)
tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C5H11NO2
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