Computed Properties of C11H24N2O2In 2020 ,《Protein degradation through covalent inhibitor-based PROTACs》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Xue, Gang; Chen, Jiahui; Liu, Lihong; Zhou, Danli; Zuo, Yingying; Fu, Tiancheng; Pan, Zhengying. The article conveys some information:
Tremendous advancements in proteolysis targeting chimera (PROTAC) technol. have been made in recent years. However, whether a covalent inhibitor-based PROTAC can be developed remains controversial. Here, we successfully developed chimeric degraders based on covalent inhibitors to degrade BTK and BLK kinases, demonstrating that covalent inhibitor-based PROTACs are viable and useful tools. In the experiment, the researchers used many compounds, for example, N-Boc-1,6-Diaminohexane(cas: 51857-17-1Computed Properties of C11H24N2O2)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Computed Properties of C11H24N2O2
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