Application of 51857-17-1In 2020 ,《A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarization》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Li, Zhihong; Zhen, Shuai; Su, Kaijun; Tumber, Anthony; Yu, Quanwei; Dong, Ying; McDonough, Michael; Schofield, Christopher J.; Zhang, Xiaojin. The article conveys some information:
Inhibition of the dioxygen sensing hypoxia-inducible factor prolyl hydroxylases has potential therapeutic benefit for treatment of diseases, including anemia. We describe the discovery of a small-mol. probe useful for monitoring binding to human prolyl hydroxylase domain 2 (PHD2) via fluorescence polarization. The assay is suitable for high-throughput screening of PHD inhibitors with both weak and strong affinities, as shown by work with clin. used inhibitors and naturally occurring PHD inhibitors. The experimental part of the paper was very detailed, including the reaction process of N-Boc-1,6-Diaminohexane(cas: 51857-17-1Application of 51857-17-1)
N-Boc-1,6-Diaminohexane(cas: 51857-17-1) is used to prepare 1,3-Bis[6-(Boc-amino)hexyl]urea by reacting with carbonyl dichloride in the presence of triethylamine. Further, it is used as a reagent for the introduction of a C6-spacer.Application of 51857-17-1
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