Adding a certain compound to certain chemical reactions, such as: 34837-84-8, name is Methyl 2-(4-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34837-84-8, category: esters-buliding-blocks
To a stirred solution of diisopropylamine (13.0 g) in tetrahydrofurane (160 mL)was added a solution of n-butyllithium in hexane (51 .4 mL; c= 2.5 M) at -78 ¡ãC.The solution was stirred at 0 ¡ãC for 15 minutes. The solution was cooled to -78¡ãC and a solution of methyl (4-fluorophenyl)acetate (18.0 g), dissolved intetrahydrofurane (40 mL) was added. The solution was stirred at -78 ¡ãC for 30 minutes. Methyl iodide (10.0 mL) was added at -78 ¡ãC, and the solution was allowed to warm up to 0 ¡ãC within 1 h. Water was added and the reaction mixture was extracted with ethyl acetate. The organic phase was dried (sodium sulfate) and the solvent was removed in vacuum. Silicagelchromatography gave 18.9 g of the title compound.1H-NMR (400MHz, DMSO-d6): 6 [ppm] = 1.34 (d, 3H), 3.55 (5, 3H), 3.79 (q, 1H),7.08 – 7.15 (m, 2H), 7.25 – 7.32 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-fluorophenyl)acetate, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; SCHULZE, Volker; LERCHEN, Hans-Georg; BIERER, Donald; WENGNER, Antje Margret; SIEMEISTER, Gerhard; LIENAU, Philip; KRENZ, Ursula; KOSEMUND, Dirk; STOeCKIGT, Detlef; BRUeNING, Michael; LUeCKING, Ulrich; TEREBESI, Ildiko; WO2014/198647; (2014); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics