Product Details of 7524-52-9In 2020 ,《Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry. The article was written by Poole, Alisha T.; Sitko, Christopher A.; Le, Caitlin; Naus, Christian C.; Hill, Bryan M.; Bushnell, Eric A. C.; Chen, Vincent C.. The article contains the following contents:
Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumor. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete surgical resection of tumors difficult. Based upon the connexin43 (Cx43) model of glioma migration we have developed a computational framework to evaluate MMP inhibition in materials relevant to GBM. Using the ilomastat Leu-Trp backbone, we have synthesized novel sulfonamides and monitored the performance of these compounds in conditioned media expressing MMP3. From the results discussed herein we demonstrate the performance of sulfonamide based MMPIs included AP-3, AP-6, and AP-7. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Product Details of 7524-52-9)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Product Details of 7524-52-9
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