154825-97-5, Name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, 154825-97-5, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
General procedure: A mixture of bromobenzene (10 g, 63.6 mmol), acetic acid (5.76 g, 96 mmol), methylamine (3.0 g-100% basis, 95.5 mmol) of 40% solution, and Cu powder (2.01 g) followed by DMF (20 mL) was heated at reflux in a 100 mL round bottom flask for 9 h. The mixture was cooled to rt, dichloromethane (200 mL) was added and then filtered to remove Cu powder. The filtrate was washed with water (200 mL) and dried over sodium sulphate and concentrated under reduced pressure. Crude sample thus obtained was purified by column chromatography (silica gel, ethyl acetate/petroleum ether, 5:95) to give N-methyl aniline (3.74 g, 55%, 1c).
Statistics shows that Methyl 2-(4-bromophenyl)-2,2-dimethylacetate is playing an increasingly important role. we look forward to future research findings about 154825-97-5.
Reference:
Article; Siddegowda, Maravanahalli S.; Yathirajan, Hemmige S.; Ramakrishna, Ramesha A.; Tetrahedron Letters; vol. 53; 39; (2012); p. 5219 – 5222;,
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