Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2475-80-1, name is Methyl 2-amino-5-methoxybenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 2475-80-1
Example 27 Synthesis scheme for the compound of formula IA2 A mixture of 6,6-dimethyl-8-oxo-3,4,5,6,7,8-hexahydro-2H-benzo[0][ l ,4]thiazine-3- carboxylate (0.54 g, 1.0 equiv) and 3 drops of DMF in dichloromethane ( l OmL) was cooled at – 10~0C. Oxalyl chloride (0.51 g, 2.0 equiv) was added dropwise into the mixture at – 10~0C, the mixture was kept at -10~0C for another 1 hour with stirring. The solution was concentrated under reduced pressure to give (R)-ethyl 8-chloro-6,6-dimethyl-3,5,6,7-tetrahydro-2H- benzo[¡ê][l ,4]thiazine-3-carboxylate as yellow oil. The residue was diluted with ethanol (1 1 niL, 20 vol), methyl 2-amino-5-methoxybenzoate (0.72 g, 2.0 equiv) was added into the (R)-ethyl 8- chloro-6,6-dimethyl-3,5,6,7-tetrahydro-2H-benzo[Z)][ l ,4]thiazine-3-carboxyIate solution, the resulting mixture was kept at 20~30C for 20 hour with stirring. The solution was concentrated under reduced pressure. The residue was purified by column chromatography (mobile phase: DCM/MeOH = 100/1-20/1) to give (¡ê)-methyl 2-((3-((2-ethoxy-2-oxoethyl)amino)-5,5- dimethylcyclohex-2-en-l -ylidene)amino)-5-methoxybenzoate.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ELKIMIA; ABOU-KHALIL, Elie; RAEPPEL, Stephane; RAEPPEL, Franck; WO2013/181741; (2013); A1;,
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