Krapcho, A Paul’s team published research in Tetrahedron Letters in 1974 | 112-63-0

Tetrahedron Letters published new progress about Carboxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Krapcho, A. Paul; Jahngen, Edwin G. E. Jr.; Kashdan, David S. published the artcile< α-Carbalkoxylations of carboxylic acids. General synthetic route to monoesters of malonic acids>, Formula: C19H34O2, the main research area is carboxylation carboxylic acid; malonic acid monoester.

Treatment of α-anions of acyclic and alicyclic carboxylic acids, prepared by reaction of the acid with LiN(CHMe2)2, with either ClCO2Et or (RO)2CO (R = Me, Et) gave 46-88% of monoesters of malonic acids. Thus, Me2CHCO2H reacted with ClCO2Et in the presence of LiN(CHMe2)2 to give 85% Me2C(CO2H)CO2Et.

Tetrahedron Letters published new progress about Carboxylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics