In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 56741-34-5 as follows. HPLC of Formula: C8H8FNO2
[00326] To a stirred solution of methyl 5-amino-2-fluorobenzoate (500 mg, 2.99 mmol) in DCM (20 mL) at 0 C, was added 3,4-difluorobenzoyl chloride (410 mu, 3.26 mmol) followed by TEA (1.0 mL, 7.48 mmol). The mixture was allowed to warm to rt and stirred for 72 h. The mixture was diluted with water and the organic layer separated and concentrated under reduced pressure. The obtained solid was purified via trituration with Et20 to afford compound 1 (782 mg, 84%) as a white solid. 1H MR (400 MHz, DMSO-i): delta 10.53 (s, 1H), 8.35 (m, 1H), 8.00 – 8.10 (m, 2H), 7.88 (m, 1H), 7.66 (m, 1H), 7.38 (m, 1H), 3.85 (s, 3H); LCMS Mass: 310.0 (M++l).
According to the analysis of related databases, 56741-34-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SIDECAR THERAPEUTICS, INC.; ROWBOTTOM, Martin W.; (183 pag.)WO2018/183122; (2018); A1;,
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