Razazpour, Fateme; Najafi, Farhood; Moshaverinia, Alireza; Fatemi, Seyyed Mostafa; Sima, Shahabi published the artcile< Synthesis and characterization of a photo-cross-linked bioactive polycaprolactone-based osteoconductive biocomposite>, Application In Synthesis of 3290-92-4, the main research area is photocrosslinked bioactive polypropylene fumarate polycaprolactone osteoconductive biocomposite tissue engineering; PCL; PPF; bio composite; bone defect; copolymer; β-TCP.
In this study, a light cross-linkable biocomposite scaffold based on a photo-cross-linkable poly (propylene fumarate) (PPF)-co-polycaprolactone (PCL) tri-block copolymer was synthesized and characterized. The developed biodegradable scaffold was further modified with β-tricalcium phosphate (β-TCP) bioceramic for bone tissue engineering applications. The developed biocomposite was characterized using H NMR and Fourier transform IR spectroscopy. Moreover, the bioceramic particle size distribution and morphol. were evaluated using Brunauer-Emmett-Teller method, X-ray diffraction, and SEM. The mech. properties and biodegradation of the scaffolds were also evaluated. Cytotoxicity and mineralization assays were performed to analyze the biocompatibility and bioactivity capacity of the developed biocomposite. The characterization data confirmed the development of a biodegradable and photo-cross-linkable PCL-based biocomposite reinforced with β-TCP bioceramic. In vitro analyses demonstrated the biocompatibility and mineralization potential of the synthesized bioceramic. Altogether, the results of the present study suggest that the photo-cross-linkable PCL-PPF-PCL tri-block copolymer reinforced with β-TCP is a promising biocomposite for bone tissue engineering applications. According to the results, this newly synthesized material has a proper chem. composition for further clin.-relevant studies in tissue engineering.
Journal of Biomedical Materials Research, Part A published new progress about Biocomposites. 3290-92-4 belongs to class esters-buliding-blocks, and the molecular formula is C18H26O6, Application In Synthesis of 3290-92-4.
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