Application of 2178-24-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl (2-bromophenyl)acetate, its application will become more common.

Synthetic Route of 2178-24-7,Some common heterocyclic compound, 2178-24-7, name is Ethyl (2-bromophenyl)acetate, molecular formula is C10H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1(4′-Methylbiphenyl-2-yl)acetic acid a) Ethyl (4′-methylbiphenyl-2-yl)acetateTo a mixture composed of 243.1 mg (1 mmol) of ethyl 2-(2-bromophenyl)- acetate, 3.7 ml of toluene, 57.8 mg (0.05 mmol) of tetrakis(triphenylphosphine)- palladium and 127.2 mg (1.2 mmol) of anhydrous sodium carbonate are added EPO 169.9 mg (1.25 mmol) of 4-methy.phenylboronic acid, followed by addition of 2.21 ml (0.055 mmol) of methanol. The reaction medium is heated at 85C for 16 hours with stirring. After cooling, 10 ml of water and 8 ml of ethyl acetate are added with stirring, and the mixture is then filtered through a fluted filter paper. The organic phase is recovered and the aqueous phase is extracted again with ethyl acetate.The combined organic phases are washed with water (2 x 10 ml), dried over Na2SO4 and then concentrated to give 310 mg of oil, which is purified by flash chromatography on a column of silica, in a dichloromethane/heptane mixture (1 :1). 201 mg of a colourless oil are obtained.Yield: 79%NMR (CDCI3): 1.2 (t, J=7.2 Hz, 3H); 2.5 (s, 3H); 3.7 (m, 2H), 4.1 (q, J=7.2 Hz, 2H); 7.3 (m, 8H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl (2-bromophenyl)acetate, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; WO2006/58592; (2006); A1;,
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