Synthetic Route of 142166-01-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 142166-01-6, name is Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
3, 4-Dihydro-2H-benzo [1, 4] oxazine-7-carboxylic acid methyl ester (52 mmol) was dissolved in MeOH (20 mL) and NaOH (2M) (20 mL) and stirred at 60 C for 48h. The organic solvent was removed by evaporation, and the aqueous phase acidified with HC1 (4M). The organic products separated as an oil, and were extracted with ethyl acetate. The organic extract was dried over MgS04, filtered and evaporated. The crude was purified by flash chromatography on silica with gradient elution (heptane/ethyl acetate). Yield: 31 % 1H NMR (D6-DMSO) : 3.33 (t, 2H); 4.10 (t, 2H); 6.51 (d, 1H); 7.16 (d, 1H); 7.30 (dd, 1H).
The chemical industry reduces the impact on the environment during synthesis Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; H. LUNDBECK A/S; WO2005/39572; (2005); A1;,
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