Qin, Chunjun; Liu, Zhonghua; Ding, Meiru; Cai, Juntao; Fu, Junjie; Hu, Jing; Seeberger, Peter H.; Yin, Jian published the artcile< Chemical synthesis of the Pseudomonas aeruginosa O11 O-antigen trisaccharide based on neighboring electron-donating effect>, SDS of cas: 4098-06-0, the main research area is glycosyl trifluoroacetimidate glycosylation galactose steric effect; Pseudomonas aeruginosa antigen trisaccharide neighboring electron donating synthesis fucosamine.
Pseudomonas aeruginosa O11 O-antigen is immunol. active but an exact protective epitope has not yet been identified. Synthesis of O11 O-antigen trisaccharide is of importance for identifying the epitopes. Here, neighboring electron-donating effects are keys to enhance the nucleophilicity of the C3 hydroxyl groups of D- and L-fucosamines, to facilitate the efficient synthesis of the trisaccharide. The disarmed peracetylated glycosyl donor with low glycosylation reactivity and glycosyl trifluoroacetimidate with good stability allowed for the glycosylation under mild conditions. The C6 nucleophilic tosylate substitution of D-galactose with iodine was found to be dependent on the steric effect of the axial C4.
Journal of Carbohydrate Chemistry published new progress about Antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 4098-06-0 belongs to class esters-buliding-blocks, and the molecular formula is C12H16O7, SDS of cas: 4098-06-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics