Reference of 2065-23-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2065-23-8 name is Methyl 2-phenoxyacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Methyl phenoxyacetate (99.9 g, 0.6 mol) was added dropwise to [CHLOROSULFONIC] acid (279.6 g, 159.5 mL, 2.4 mol) at-5 C at such a rate to maintain internal temperature between 0 to-5 C (addition took about 60 min). Some solid formed during this addition. The cooling bath was removed and the reaction mixture was stirred at room temperature for an additional 1.5 hr. The reaction mixture was poured into a vigorously stirring mixture of dichloromethane (900 mL) and methanol (100 [ML)] at [0 C.] After 15 min the cooling bath was removed and the resulting mixture was stirred at room temperature for 1 hr. The resulting mixture was washed with ice cold water (2 X 250 mL). The combined aqueous layers were back extracted with dichloromethane [(1] X 250 mL). The combined organic layers were washed with brine [(1 X] 200 mL), dried over anhydrous magnesium sulfate (15 g) and concentrated under reduced pressure to give 132 g (83%) of the title compound as a white solid.’H NMR [(60MHZ)] [(CDC13)] 8 8.2-7. 2 (AB, 4H), 4.95 (s, 2H), 3.95 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-phenoxyacetate, and friends who are interested can also refer to it.
Reference:
Patent; GARST, Michael, E.; SACHS, George; SHIN, Jai, Moo; WO2004/9583; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics