Dinca, Emanuela; Hartmann, Philip; Smrcek, Jakub; Dix, Ina; Jones, Peter G.; Jahn, Ullrich published the artcile< General and Efficient α-Oxygenation of Carbonyl Compounds by TEMPO Induced by Single-Electron-Transfer Oxidation of Their Enolates>, Formula: C6H10O5, the main research area is alpha oxygenated carbonyl compound preparation; regioselective oxygenation carbonyl compound single electron transfer oxidation; stable free radical TEMPO coupling carbonyl compound; piperidinyloxy ketone ester amide acid nitrile preparation; enolate aggregate influence oxygenation reactions significantly; chemoselective reduction piperidinyloxy compound; hydroxy alpha carbonyl compound preparation; monoprotected diol preparation; amino alc protected preparation.
A generally applicable method for the synthesis of protected α-oxygenated carbonyl compounds is reported. It is based on the single-electron-transfer oxidation of easily generated enolates to the corresponding α-carbonyl radicals. Coupling with the stable free radical TEMPO provides α-(piperidinyloxy) ketones, esters, amides, acids or nitriles in moderate-to-excellent yields. Enolate aggregates influence the outcome of the oxygenation reactions significantly. Competitive reactions have been analyzed and conditions for their minimization are presented. Chemoselective reduction of the products led to either N-O bond cleavage to α-hydroxy carbonyl compounds or reduction of the carbonyl functionality to monoprotected 1,2-diols or O-protected amino alcs.
European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (enolization and TEMPO-induced single-electron-transfer oxidation of). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics