Rajeswari, Doodigama; Anil, Kumar V. published the artcile< Method development and validation for the simultaneous estimation of lamivudine and stavudine by RP-HPLC>, Electric Literature of 112-63-0, the main research area is lamivudine stavudine reversed phase high performance liquid chromatog.
The proposed method was found to be simple, sensitive, rapid and economical for the determination of Lamivudine and Stavudine in combined tablet formulation. The developed method was checked for the performance characteristics and has also been validated. The method was found to be linear (r>0.999), precise (RSD: 0.41 for Lamivudine, 0.10 for Stavudine) and accuracy (mean percentage recovery fields 98.7% for Lamivudine, 99.1% for Stavudine). The proposed HPLC method was simple, precise because of commonly used buffer and shorter run time. The mean percentage recovery above 95% indicates the reproducibility and accuracy of new developed method compared. The result of study include the proposed method is highly accurate, simple, precise and specific. The sample recoveries in all formulations were in good agreement with their resp. label claims and they suggest non-interference of formulation excipients in the estimation After validating proposed method as per ICH guidelines and correlating obtained values with the standard values, satisfactory results were obtained. Hence the method can easily and conveniently adopted for the estimation of combined dosage form of Lamivudine and Stavudine.
International Journal of Science and Research Methodology published new progress about Agrochemical tablets. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics