Xie, Caixia; Li, Songhua; Li, Yunyi; Ma, Chen published the artcile< An efficient route for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives promoted by CBr4 in one pot>, Synthetic Route of 94-02-0, the main research area is benzoimidazolyl benzamide preparation.
A metal-free one-pot method for the synthesis of N-(1H-benzo[d]imidazol-2-yl)benzamide derivatives such as I [R1 = Ph, 4-MeC6H4, 1-naphthyl, etc.; R2 = Me, Et, Ph] and N-(1H-imidazol-2-yl)benzamide derivatives II [R3 = 4-ClC6H4, 4-MeOC6H4, 4-CF3C6H4, etc.; R4 = Et, Me] was proposed mediated by CBr4. The reaction went through ring formation and opening processes with only two protons leaving and the thermodynamically favorable products were selectively formed in moderate to good yields. Easily accessible starting materials, simple operations and high atom economy made this strategy a potential and useful method in organic and pharmaceutical chem.
Tetrahedron published new progress about Atom economy. 94-02-0 belongs to class esters-buliding-blocks, and the molecular formula is C11H12O3, Synthetic Route of 94-02-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics