Yoshioka, Hiromasa; Kawamura, Tatsuro; Muroi, Makoto; Kondoh, Yasumitsu; Honda, Kaori; Kawatani, Makoto; Aono, Harumi; Waldmann, Herbert; Watanabe, Nobumoto; Osada, Hiroyuki published the artcile< Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)>, Product Details of C15H22N2O2, the main research area is anticancer GPX4 FSP1 inhibitor NPD4928 synergistic effects ferroptosis enhancer.
Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while reducing lipid peroxides, and is a promising target for cancer therapy. Till date, several GPX4 inhibitors have been reported to exhibit cytotoxicity against cancer cells. However, some cancer cells are less sensitive to the known GPX4 inhibitors. This study aimed to explore compounds showing synergistic effects with GPX4 inhibitors. We screened a chem. library and identified a compound named NPD4928 (I), whose cytotoxicity was enhanced in the presence of a GPX4 inhibitor. Furthermore, we identified ferroptosis suppressor protein 1 (FSP1) as its target protein. The results indicate that NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting the combination to possibly have therapeutic potential via the induction of ferroptosis.
ACS Chemical Biology published new progress about Antitumor agents. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics