Synthetic Route of C7H12O3In 2021 ,《Synthesis and pharmacological evaluation of novel benzimidazole derivatives as antiulcer and H+ K+ ATPase inhibitor》 appeared in Journal of Advances in Medical and Pharmaceutical Sciences. The author of the article were Khan, Farhan R.; Farooqui, Mohd. Saleemuddin. The article conveys some information:
A series of new 2-[(substituted-pyrimidin-4-yl) sulfinyl]-1H-benzimidazoles I [R1 = H, Me, nitro; R2 = Me, Et, propyl] were synthesized by the condensation of O-phenylenediamine, KOH and CS2 resulting potassium 1-H-benzimidazole 2-thiolate further treated with glacial acetic acid gives 1H-benzimidazole 2- thiol (2-mercaptobenzimidazole). 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol prepared by ethanimidamide and alkyl acetoacetate gives 2-Me, 6-Alkylpyrimidine-4-ol by chlorination using thionyl chloride 4-Chloro 2 Me, 6-Alkylpyrimidine- 4-ol was obtained. Further reacted with sodium oxide followed by m-chloroperbenzoic finally gives 2-[(substituted-pyrimidin-4-yl) sulfinyl]- 1H-benzimidazole. Structural characterization of these synthesized compounds I was confirmed by FT-IR, 1HNMR, and Mass spectral data. Later synthesized derivatives evaluated for their antiulcer and H+ K+ ATPase inhibitory activity by aspirin induced method and assays of H+/K+-ATPase activity resp. Compound I [R1 = H; R2 = methyl] (74.03%), I [R1 = methyl; R2 = propyl] (72.87%) and I [R1 = nitro; R2 = propyl] (75.15%) shows highly significant antiulcer activity compared to standard drug and compound I [R1 = H; R2 = propyl] (88.88%), I [R1 = R2 = methyl] (91.03%), I [R1 = methyl; R2 = propyl] (86.48%) and I [R1 = nitro; R2 = methyl] (84.21%) shows highly significant antisecretory activity when compare to standard drug. These research work provoked further to work for development of different derivatives of 2-(pyrimidinyl-sulfinyl) benzimidazole I which have lesser side effect and better action than few of marketed drugs. The results came from multiple reactions, including the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Synthetic Route of C7H12O3)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Synthetic Route of C7H12O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics