Product Details of 16982-21-1In 2018 ,《Synthesis and QSAR study of novel thiazole moieties having antioxidant activity》 was published in International Journal of Pharmaceutical Sciences and Research. The article was written by Kashid, G. A.; Singh, S. K.; Saravanan, J.. The article contains the following contents:
Thiazoles derivatives are an important class of heterocyclic compounds, reported to possess a wide spectrum of biol. activities. Moreover, thiazole nucleus occupies a very important place in the field of antioxidant agents. The above observations prompted us to synthesize some novel thiazole derivatives with various substitutions at along with heterocyclic rings in the same framework for synergistic action. We here in report the synthesis, antioxidant screening & QSAR studies of the new title compounds Concentrated research on N-((Substituted) benzylidene)-4-(4-chlorophenyl) thiazole-2-carbohydrazides I [R = 4-Cl; R1 = 4-Me, 4-Cl, 3-nitro, etc.] & were synthesized, screened for antioxidant activities & QSAR studies. All new entities have good yield and results. From antioxidant activity results, it was observed that the compounds with both electron donating and electron withdrawing groups on the aldehydic Ph ring influenced the activity. Among all the compounds, compounds I [R = 4-Cl, R1 = 4-hydroxy-3-methoxy, 3,4,5-trihydroxy, 4-methoxy, 4-Cl, 4-hydroxy] showed the good % inhibition and were found to be more significant compound among all the compounds tested. Compounds GS-5i-j were showed moderate % inhibition and were found to be significant among all the tested compounds 2D & 3D-QSAR models with moderate to high predictive ability of thiazole derivatives were derived. The role of hydrophobicity as a 3D property was confirmed and also electrostatic and steric effects were found to contribute to antioxidant activity. The experimental process involved the reaction of Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1Product Details of 16982-21-1)
Ethyl 2-amino-2-thioxoacetate(cas: 16982-21-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 16982-21-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics