Zheng, Shuai; Zhang, Shuo-Qing; Saeednia, Borna; Zhou, Jiawang; Anna, Jessica M.; Hong, Xin; Molander, Gary A. published the artcile< Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights>, Product Details of C11H15NO3, the main research area is lactam preparation regioselective diastereoselective DFT Gibbs free energy; alkene iridium nickel photocatalyst amidoacylation cyclization.
Synthesis of cyclic amides such as I via regio- and diastereoselective amidoacylation of unactivated olefins by using photoredox proton-coupled electron transfer (PCET)/Ni dual-catalysis was developed. Various acyl electrophiles were compatible, including alkyl- and aryl acyl chlorides and anhydrides, as well as in situ activated carboxylic acids. Hammett studies and other mechanistic experiments to elucidate features of the diastereoselectivity, a transient absorption study of the PCET step, as well as computational evidence, provide an in-depth understanding of the disclosed transformation.
Chemical Science published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Product Details of C11H15NO3.
Referemce:
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