Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22223-49-0, name is Methyl 2-amino-3-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H11NO2
To a solution of methyl 2-amino-3-methylbenzoate (4) (1.00 g, 6.10 mmol) in DMF (10 ml) was added NBS (1.10 g, 6.10 mmol), and the reaction mixture was stirred at rt for 6 h. The reaction mixture was diluted with EtOAc (10 ml) and washed with saturated aqueous Na2CO3 solution (10 ml * 3). The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexanes/EtOAc = 100:1) to give compound 5 as pale gray solid (0.93 g, 62% yield): 1H NMR (400 MHz, CDCl3) delta (ppm) 7.88 (d, J = 2.3 Hz, 1H), 7.28 (d, J = 2.3 Hz, 1H), 5.82 (s, 2H), 3.86 (s, 3H), 2.15 (s, 3H).
According to the analysis of related databases, 22223-49-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kim, Mi Kyoung; Shin, Heerim; Cho, Seo Young; Chong, Youhoon; Bioorganic and Medicinal Chemistry; vol. 22; 3; (2014); p. 1156 – 1162;,
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