According to the analysis of related databases, 105-53-3, the application of this compound in the production field has become more and more popular.
Synthetic Route of 105-53-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 105-53-3 as follows.
Synthesis of 2-ethoxycarbonyl-malonic acid diethyl ester; Magnesium turnings (1.25 g, 50.2 mmol), dry ethanol (5 ml.) and CCI4 (0.5 ml_) were taken in a dry 100 mL of three neck flask and it was heated at 80 0C for 6 h. To this was added a mixture of diethyl malonate (8 g, 50.2 mmol) and dry ethanol (14 mL) and stirred for 2 h. The reaction EPO betamixture was cooled in a water bath when crystals were formed. After this, dry THF (20 mL) was added drop wise to dissolve the solid formed and heated for 1 h at 80 0C. To this was then added ethyl chloroformate (5 mL, 50.2 mmol) in dry THF while keeping constant boiling and the heating was further continued for 1 h followed by bringing the reaction mixture to room temperature, poured into dilute acetic acid (4 mL acetic acid in 15 mL water). This was extracted with ethyl acetate, washed with brine and the organic layers were combined and dried over anhydrous Na2SO4 and concentrated to give yellow liquid. The unreacted diethyl malonate was then removed by vacuum distillation to get the pure product as a colorless liquid. 1H NMR (300 MHz, CDCI3): 1.31 (t, 9H), 4.28 (q, 6H), 4.41 (s, 1 H). Mass: 233 (M++1).
According to the analysis of related databases, 105-53-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; INDIAN INSTITUTE OF TECHNOLOGY BOMBAY; WO2006/117800; (2006); A2;,
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