Rational Development of Remote C-H Functionalization of Biphenyl: Experimental and Computational Studies was written by Fan, Zhoulong;Bay, Katherine L.;Chen, Xiangyang;Zhuang, Zhe;Park, Han Seul;Yeung, Kap-Sun;Houk, K. N.;Yu, Jin-Quan. And the article was included in Angewandte Chemie, International Edition in 2020.Recommanded Product: 14667-47-1 This article mentions the following:
A simple and efficient nitrile-directed meta-C-H olefination, acetoxylation, and iodination of biaryl compounds was reported. Compared to the previous approach of installing a complex U-shaped template to achieve a mol. U-turn and assemble the large-sized cyclophane transition state for the remote C-H activation, a synthetically useful Ph nitrile functional group could also direct remote meta-C-H activation. This reaction provided a useful method for the modification of biaryl compounds because the nitrile group was readily converted to amines, acids, amides or other heterocycles. Notably, the remote meta-selectivity of biphenylnitriles could not be expected from previous results with a macrocyclophane nitrile template. DFT computational studies showed that a ligand-containing Pd-Ag heterodimeric transition state (TS) favors the desired remote meta-selectivity. Control experiments demonstrated the directing effect of the nitrile group and exclude the possibility of non-directed meta-C-H activation. Substituted 2-pyridone ligands were found to be key in assisting the cleavage of the meta-C-H bond in the concerted metalation-deprotonation (CMD) process. In the experiment, the researchers used many compounds, for example, Methyl 2-aminonicotinate (cas: 14667-47-1Recommanded Product: 14667-47-1).
Methyl 2-aminonicotinate (cas: 14667-47-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Recommanded Product: 14667-47-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics