Retro-inverso tripeptide renin inhibitors was written by Patel, Dinesh V.;Ryono, Denis E.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1992.Synthetic Route of C11H20O4 This article mentions the following:
Retro-inverso tripeptide renin inhibitors I and II were prepared as backbone modifications of tripeptide alc. renin inhibitor Boc-Phe-His-Leu-ol (III) (I50 = 16 μM). While the diastereomeric mixture of partial retro analog II was substantially less active (I50 = 1,200 μM), the complete retro-inverso modification was well tolerated as evidenced by the equipotency of a diastereomer of I (I50 = 20 μM) to parent compound III. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C11H20O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics