Month: July 2023

Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding was written by Menichincheri, Maria;Albanese, Clara;Alli, Cristina;Ballinari, Dario;Bargiotti, Alberto;Caldarelli, Marina;Ciavolella, Antonella;Cirla, Alessandra;Colombo, Maristella;Colotta, Francesco;Croci, Valter;D’Alessio, Roberto;D’Anello, Matteo;Ermoli, Antonella;Fiorentini, Francesco;Forte, Barbara;Galvani, Arturo;Giordano, Patrizia;Isacchi, Antonella;Martina, Katia;Molinari, Antonio;Moll, Jurgen K.;Montagnoli, Alessia;Orsini, Paolo;Orzi, Fabrizio;Pesenti, Enrico;Pillan, Antonio;Roletto, Fulvia;Scolaro, Alessandra;Tato, Marco;Tibolla, Marcellino;Valsasina, Barbara;Varasi, Mario;Vianello, Paola;Volpi, Daniele;Santocanale, Corrado;Vanotti, Ermes. And the article was included in Journal of Medicinal Chemistry in 2010.Computed Properties of C9H10O3S This article mentions the following:

Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small mols. causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in primary fibroblasts. This implies that Cdc7 kinase could be considered a potential target for anticancer therapy. We previously reported that pyrrolopyridinones are potent and selective inhibitors of Cdc7 kinase, with good cellular potency and in vitro ADME properties but with suboptimal pharmacokinetic profiles. Here we report on a new chem. class of 5-heteroaryl-3-carboxamido-2-substituted pyrroles that offers advantages of chem. diversification and synthetic simplification. This work led to the identification of (aminopyrimidinyl)phenylpyrrolecarboxamide I, with biochem. data and ADME profile similar to the originally reported pyrrolopyridinones but characterized by superior efficacy in an in vivo model. Derivative I represents a new lead compound worthy of further investigation toward the ultimate goal of identifying a clin. candidate. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Computed Properties of C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

GCMS and FTIR spectral analysis of aqueous methylparathion biotransformation by the microbial mpd strains of Pseudomonas aeruginosa and Fusariumspp was written by Krishnaswamy, Usharani. And the article was included in Archives of Microbiology in 2021.Formula: C6H12O2 This article mentions the following:

This study aimed to find out the effective biotreatment processes of aqueous methyl parathion in stipulations of its biotransformation by potential indigenous mpd strains of Pseudomonas aeruginosa and Fusariumspp. Microbial biotransformation study of methyl parathion in contaminated synthetic wastewater at optimum conditions by P. aeruginosa mpd-5 (at temperature 33 °C, pH 7, under the aerobic condition with inoculum d. of 10⁸cells/mL) and by Fusarium spp mpd-1 (at temperature 30 °C, pH 7, under the aerobic condition with inoculum d. of 25 mgL^-1 dry biomass) was carried out. The major biodegradation compounds formed during the biotreatment process were analyzed by spectral studies using GCMS and FTIR. GCMS anal. of bacterial transformed compounds was p-nitrophenol, dimethylaminophenol, and glycyl-L-proline of 2-(3-methylpiperidino-4-5, 6-benzothiazin-4-one) and 2, 5-piperazinodione 3, 6-bis (2-methylpropyl). And the fungal transformed compounds were observed to be p-nitrophenol, phenol,2,4-Bis(1,1-Dimethylethyl), beta-L-arabinopyranoside-Me, Cyclobutanethiol, 3-2(4)-thiophenone, dihydro-5-(1-methylethyl), Benzene,1,3-bis(1,1-di-Me ethyl), Butanoic acid, 2-Me Me ester, and L-(+)-Ascorbic acid. The FTIR spectra of the mol. and the products of methyl parathion are observed to be changed in structures. It can be concluded from the aforementioned results and discussions that P. aeruginosa mpd-5 and Fusarium spp mpd-1 can be used in the biotreatment of pesticide wastewater having the high methyl parathion concentration and is possible by the indigenous microbial strains; they utilize as phosphate and carbon source of energy. Hence the strains can be used as a whole microbial cell, or its bioactive metabolites can be applied for the biotreatment of pesticide wastewater and potentially degrade methylparathion. In the experiment, the researchers used many compounds, for example, Methyl2-methylbutyrate (cas: 868-57-5Formula: C6H12O2).

Methyl2-methylbutyrate (cas: 868-57-5) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Formula: C6H12O2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics