Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors was written by Zhang, Jiankang;Cao, Jiayi;Xu, Lei;Zhou, Yubo;Liu, Tao;Li, Jia;Hu, Yongzhou. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Recommanded Product: 87694-53-9 This article mentions the following:
A series of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid were designed, synthesized and evaluated as proteasome inhibitors. All target compounds were tested for their proteasome inhibitory activities and selected compounds were tested for their anti-proliferation activities against two multiple myeloma (MM) cell lines RPMI 8226 and NCI-H929. Among them, eleven compounds exhibited proteasome inhibitory rates of more than 50% at the concentration of 1 μg/mL and nine compounds showed anti-proliferation activities with IC50 values at low micromolar level. Compound I displayed the most potent proteasome inhibitory activities (IC50 = 0.11 ± 0.01 μM) and anti-proliferation activities with IC50 = 0.23 ± 0.01 and 0.17 ± 0.02 μM against two tested cell lines. Addnl., the poly-ubiquitin accumulation in the western blot anal. supported that proteasome inhibition in a cellular system was induced by compound I. All these exptl. results confirmed that β-amino acid can be introduced as a building block for the development of proteasome inhibitors. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Recommanded Product: 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: 87694-53-9
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics