Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents was written by Spallarossa, Andrea;Caneva, Chiara;Caviglia, Matteo;Alfei, Silvana;Butini, Stefania;Campiani, Giuseppe;Gemma, Sandra;Brindisi, Margherita;Zisterer, Daniela M.;Bright, Sandra A.;Williams, Clive D.;Crespan, Emmanuele;Maga, Giovanni;Sanna, Giuseppina;Delogu, Ilenia;Collu, Gabriella;Loddo, Roberta. And the article was included in European Journal of Medicinal Chemistry in 2015.HPLC of Formula: 62020-09-1 This article mentions the following:
A new series of indole-based analogs were recently identified as potential anticancer agents. The Knoevenagel-type indoles herein presented were prepared via a one-pot condensation of iminium salts with active methylene reagents and were isolated as single geometric isomers. Biol. evaluation in different cell-based assays revealed an antiproliferative activity for some analogs already in the nanomolar range against leukemia, breast and renal cancer cell lines. To explain these effects, the most promising analogs of the series were engaged in further cell-based studies. Compounds I [R1 = R3 = H, R2 = Ph, X = CN, Y = thien-2-yl-(E), SO2Ph-(E); R1 = R3 = H, R2 = Ph, X = C(:O)Me, Y = SO2Ph-(E); R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = CN, SO2Ph-(E)] highlighted a pro-apoptotic potential being able to induce apoptosis in HL60, K562 and MCF-7 cell lines in a dose and time-dependent manner. The ability of these compounds to arrest cell cycle at the G2/M phase inspired the immunofluorescence studies which allowed us to identify tubulin as a potential target for compounds (E)-I [R1 = R3 = H, R2 = Ph, X = CN, Y = SO2Ph; R1 = R3 = H, R2 = C6H4OMe-4, X = CN, Y = SO2Ph]. In the experiment, the researchers used many compounds, for example, Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1HPLC of Formula: 62020-09-1).
Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.HPLC of Formula: 62020-09-1
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics