Phthalates exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological literature was written by Praveena, Sarva Mangala;Munisvaradass, Rusheni;Masiran, Ruziana;Rajendran, Ranjith Kumar;Lin, Chu-Ching;Kumar, Suresh. And the article was included in Environmental Science and Pollution Research in 2020.SDS of cas: 84-61-7 This article mentions the following:
Epidemiol. studies have proven that children mental health can be affected by environmental pollutants which are believed to be visible in the form of psychol. disorder later in their childhood. Moreover, the effects of children mental health are evidently clear in the case of phthalates which have been observed to increase psychol. disorder, specifically attention-deficit hyperactivity disorder (ADHD). Hence, the present study aims to conduct a systematic review and provide an overview of the existing literature on the association between urinary phthalate metabolite concentrations and ADHD symptoms among children by emphasizing the confounding factors and limitations. Addnl., this review addressed the possible phthalate mechanism insights in human body including its impact on ADHD symptoms. In this case, 16 epidemiol. studies (five cross-sectional, nine cohort and two case control studies) that met all the inclusion criteria were selected out of the total of 427 papers screened to show varying quant. associations between phthalate exposure and ADHD symptoms among children with confounding factors and limitations in the existing studies in regard to the exposure and outcomes. This review also attempted to present possible explanation on phthalate mechanism in children body and its connection on neurodevelopment and ADHD symptom development which remains unclear in most of the studies. Finally, it is highly recommended for further research to carefully design cohort studies from prenatal to later childhood development with a complete sample size in order to understand phthalate impacts on children health. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7SDS of cas: 84-61-7).
Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 84-61-7
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics