Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened was written by Munchhof, Michael J.;Li, Qifang;Shavnya, Andrei;Borzillo, Gary V.;Boyden, Tracey L.;Jones, Christopher S.;LaGreca, Susan D.;Martinez-Alsina, Luis;Patel, Nandini;Pelletier, Kathleen;Reiter, Larry A.;Robbins, Michael D.;Tkalcevic, George T.. And the article was included in ACS Medicinal Chemistry Letters in 2012.Recommanded Product: 16413-26-6 This article mentions the following:
Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncol. area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inherent in lead structure 1 that resulted in the identification of Smoothened inhibitor 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (PF-04449913, 26), which has been advanced to human clin. studies. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics