Palladium-Catalyzed Carbonylative Direct Transformation of Benzyl Amines under Additive-Free Conditions was written by Li, Yahui;Wang, Zechao;Wu, Xiao-Feng. And the article was included in ACS Catalysis in 2018.Electric Literature of C7H8O2S This article mentions the following:
In this communication, authors developed a new procedure for the direct carbonylative transformation of benzyl amines. Using di-Me carbonate as the solvent, Me 2-arylacetates can be produced in good to excellent yields from the corresponding primary, secondary, and tertiary benzyl amines with palladium as the catalyst. Notably, no base or any other additive is required here. In addition, the procedure can also be applied in the preparation of methylphenidate, which is a marketing drug and used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Electric Literature of C7H8O2S).
Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C7H8O2S
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics