Continuous-Flow Synthesis of β-Ketoesters and Successive Reactions in One-Flow using Heterogeneous Catalysis was written by Kandasamy, Mohanraj;Ishitani, Haruro;Kobayashi, Shu. And the article was included in Advanced Synthesis & Catalysis in 2022.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate This article mentions the following:
A continuous-flow procedure for the synthesis of β-keto esters R1C(O)CH2CO2R2 (R1 = cyclopropyl, cyclohexyl, n-nonyl, Ph, PhCH:CH, etc., R2 = Et; R1 = PhCH2CH2, R2 = Et, i-Pr, t-Bu, Ph, PhCH2) has been developed through Roskamp reaction between aldehydes R1CHO and α-diazo esters N2:CHCO2R2 in the presence of a Sn-MCM-41 catalyst. The viability of this methodol. was confirmed with a range of aldehydes and diazo esters and provided good to excellent yields. Catalyst activity was tested over three days (84 h) of operation, and the yield of the desired β-keto ester was maintained between 73 to 89%. The prepared β-keto esters were smoothly transformed into coumarin derivatives and 5-pyrazolone through condensation reactions in a sequential flow. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate).
Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: Ethyl 3-oxo-3-(m-tolyl)propanoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics