Synthesis of Hydantoins and Thiohydantoins Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold was written by Blanco-Ania, Daniel;Hermkens, Pedro H. H.;Sliedregt, Leo A. J. M.;Scheeren, Hans W.;Rutjes, Floris P. J. T.. And the article was included in Journal of Combinatorial Chemistry in 2009.Related Products of 16413-26-6 This article mentions the following:
The synthesis of a 144-compound library of hydantoins and thiohydantoins spiro-fused to pyrrolidines, e.g. I (R = Et, t-Bu, phenethyl, etc.), is described. These compounds are synthesized from β-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in compounds active in the central nervous system. All possible stereoisomers of the two-stereocenter products are synthesized. The 80-membered hydantoin sublibrary was obtained with yields ranging from 58 to 100% (87% average) and purities from 51 to 100% (87% average) and the 64-membered thiohydantoin sublibrary was obtained with yields ranging from 65 to 100% (89% average) and purities from 67 to 100% (93% average). In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Related Products of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics