An expedient conversion of 浼?amino acids into Weinreb amides using COMU as a coupling agent was written by Tyrrell, Elizabeth;Brawn, Peter;Carew, Mark;Greenwood, Iain. And the article was included in Tetrahedron Letters in 2011.Product Details of 87694-53-9 This article mentions the following:
The use of COMU, as a non-hazardous partner, in the coupling of N-Boc 浼?amino acids with N-methoxy-N-methylamine to afford the corresponding Weinreb amides is discussed. From a practical point of view the reaction can be monitored visually by virtue of the color change associated with the conversion of substrates (yellow) into the products (orange). As the byproducts of the reaction are conveniently water-soluble, the products are isolated relatively pure and with minimal racemization. These factors coupled with the short reaction time make this a very useful procedure. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Product Details of 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Product Details of 87694-53-9
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics