Initial studies on the synthesis of the antitumor agent CC-1065. 3,4-Disubstituted pyrroles and 3,3′-bipyrroles was written by Magnus, Philip;Or, Yat Sun. And the article was included in Journal of the Chemical Society, Chemical Communications in 1983.Computed Properties of C8H11NO2 This article mentions the following:
Et sorbate with 4-MeC6H4SO2CH2NC (I) and NaH in Me2SO-Et2O at 20鎺?for 3 h gave 80% 3,4-disubstituted pyrrole II (R = H) (III). The sulfone II (R = SO2Ph), prepared from III in 90% yield, was treated with I, HN(SiMe3)2, and NaH in THF at O鎺?for 10 min to give 85% 3,3′-bipyrrole IV (R1 = H). II (R = SO2Ph) with 4-MeC6H4SO2CH(NC)CH2CH:CH2 gave the 3,3′-bipyrrole IV (R1 = allyl). In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Computed Properties of C8H11NO2).
Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C8H11NO2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics