Synthesis of N-[4-hydroxy(alkoxy, acyloxy)-3-alkoxy-benzylidene]-1-(1-adamantyl)ethanamines from 1-(1-adamantyl)ethanamine hydrochloride (Rimantadine) was written by Dikusar, E. A.;Kozlov, N. G.. And the article was included in Russian Journal of Organic Chemistry in 2007.Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:
Reactions of 1-(1-adamantyl)ethanamine hydrochloride with substituted aromatic aldehydes gave previously unknown Schiff bases containing an adamantane fragment. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate).
4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application In Synthesis of 4-Formyl-2-methoxyphenyl isobutyrate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics