New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas was written by Temal, Taoues;Jary, Helene;Auberval, Marielle;Lively, Sarah;Guedin, Denis;Vevert, Jean-Paul;Deprez, Pierre. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Product Details of 16413-26-6 This article mentions the following:
Starting from Fendiline and R-568, a novel series of urea compounds, e.g. I [R1 = H, i-Bu, t-BuO2CCH2, 2-(4-morpholinyl)ethyl, etc.; R2 = 4-Me, 3-MeO2C, 2-thiazolyl, etc.], was identified as pos. allosteric modulators of the calcium sensing receptor (CaSR), as part of a program to identify novel therapeutics for secondary hyperparathyroidism. Initially identified disubstituted ureas were converted to trisubstituted urea lead I [R1 = 2-(4-morpholinyl)ethyl; R2 = 3-MeO2C], which was further modified to increase in vivo potency. Replacing a carbomethoxy substituent by various bioisosteres led to compound I [R1 = 2-(4-morpholinyl)ethyl; R2 = 5-oxazolyl] which exhibited potent in vitro and in vivo activity after oral administration. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Product Details of 16413-26-6).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 16413-26-6
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics