Efficient Syntheses of Rugulosin Analogues was written by Snider, Barry B.;Gao, Xiaolei. And the article was included in Journal of Organic Chemistry in 2005.Quality Control of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:
Oxidation of anthracen-1-ones I (R = OH, R1 = H; R = R1 = Me; R = CH2OAc, R1 = Me) with Pb(OAc)4 in AcOH for 20 min at 25鎺矯 and 1 h at 75鎺矯 gave flavoskyrin-type dimers, e.g. II, in 53-86% yield. Heating a solution of the flavoskyrin-type dimers in pyridine under air for 1 h at 75-80鎺矯 and then for 1-2 h at 110鎺矯 afforded rugulosin-type dimers, e.g. III, in 61-88% yield. This two-step sequence provides a practical route to this unusual natural product skeleton. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Quality Control of Methyl 2-methoxy-4-methylbenzoate).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 2-methoxy-4-methylbenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics