Malonic ester and acetoacetic ester synthesis of 2-[11,14C]methyl-fatty acids was written by Ogawa, Koji;Sasaki, Motiji;Nozaki, Tadashi. And the article was included in Applied Radiation and Isotopes in 1997.Synthetic Route of C11H20O4 This article mentions the following:
Suitable conditions were sought for the synthesis of various 2-[11,14C]methyl-fatty acids by malonic ester synthesis and acetoacetic ester synthesis, both involving radio-methylation with [11,14C]H3I. The malonic ester synthesis gave 2-[11C]methyl-fatty acids with >60% decay-corrected yields in 閳?0 min and the [14C] products with somewhat higher yields at longer time. In the acetoacetic ester synthesis, several 2-[14C]methyl-fatty acids were synthesized in 50-70% yields, together with byproduct ketones, by hydrolysis of the radiomethylated acetoacetates with concentrated KOH solution. This hydrolysis was completed in 5 min at 70鎺? whereas rather drastic conditions or a longer time were needed for the thermal decarboxylation in the malonic ester synthesis. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C11H20O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics