Optically active N- and C-terminal building blocks for the synthesis of peptidyl olefin peptidomimetics was written by Mirilashvili, Sima;Chasid-Rubinstein, Naama;Albeck, Amnon. And the article was included in European Journal of Organic Chemistry in 2010.Recommanded Product: 10203-58-4 This article mentions the following:
Peptidyl olefin peptidomimetics serve as biol. active compounds or as intermediates for other peptidyl isosteres. The N-terminal side of the C:C bond could be easily prepared in an optically pure form from 浼?amino acids. Synthesis of C-terminal building blocks in an optically pure form is more challenging. They include an electrophilic aldehyde and nucleophilic sulfone, phosphonium salt, phosphonate, and diselenide. Key enzymic hydrolysis of prochiral diesters to the corresponding hydroxy esters introduces optical activity. The sequence of the subsequent chem. reactions, either protection-hydrolysis-functionalization or functionalization-hydrolysis-protection, determines the absolute stereochem. of the final building blocks. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: 10203-58-4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 10203-58-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics