Syntheses of 5-fluorouracil-fat conjugates and evaluation of their in vitro cytotoxic activity was written by Lee, Heejoo;Chang, Pan Sup;Kim, Jae Wan;Jung, Ki Hwa;Shin, Soon Hee;Shin, Hae Soon;Jung, Soon Bog. And the article was included in Yakhak Hoechi in 1990.Category: esters-buliding-blocks This article mentions the following:
Fluorouracil amides I [R = (CH2)10Me, (CH2)16Me, (CH2)7(CH:CHCH2)2Bu, (CH2)7(CH:CHCH2)3Me, (CH2)10CO2Me] were prepared as prodrugs by heating 5-fluorouracil in the RNCO. Preliminary testing for their antitumor effect was carried out on leukemia L1210 cells in culture. Most I, like fluorouracil, exhibited <50% inhibition growth at 1 鑴?10-7M. Only I [R = (CH2)10CO2Me] showed >50% inhibition at the same level. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Category: esters-buliding-blocks).
12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics