The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: A novel potent antibacterial analog derived from hygromycin A was written by Le, Phuong T.;Brickner, Steven J.;Wade, Sarah K.;Brighty, Katherine;Monahan, Rhonda;Stone, Gregory G.;Girard, Dennis;Finegan, Steve;Duignan, Joan;Schafer, John;Maloney, Meghan;Zaniewski, Richard P.;Connolly, Ann G.;Liras, Jennifer;Bordner, Jon;Samardjiev, Ivan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application of 98231-07-3 This article mentions the following:
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4′-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluorination of the Ph found in Hygromycin A, are discussed. In the experiment, the researchers used many compounds, for example, Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3Application of 98231-07-3).
Methyl 3,3-dimethoxycyclobutanecarboxylate (cas: 98231-07-3) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 98231-07-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics