Electroreductive 4-pyridylation of unsaturated compounds using gaseous ammonia as a hydrogen source was written by Ding, Weijie;Sheng, Jie;Li, Jin;Cheng, Xu. And the article was included in Organic Chemistry Frontiers in 2022.Application of 13669-10-8 This article mentions the following:
Electrochem. radical-cross-coupling with ammonia as a terminal reductant was reported in the reactions of 浼?Keto esters, 灏?keto esters, 浼?灏?unsaturated esters, and 浼?灏?unsaturated ketones with 4-CN pyridine. More than 50 corresponding pyridylation products were synthesized under constant current conditions using thiourea as an essential promoter to activate the intermediate derived from 4-CN pyridine. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8Application of 13669-10-8).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 13669-10-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics