Sulfone-based probes unraveled dihydrolipoamide S-succinyltransferase as an unprecedented target in phytopathogens was written by Chen, Biao;Long, Qingsu;Zhao, Yongliang;Wu, Yuanyuan;Ge, Shasha;Wang, Peiyi;Yang, Cai-Guang;Chi, Yonggui;Song, Baoan;Yang, Song. And the article was included in Journal of Agricultural and Food Chemistry in 2019.Product Details of 180636-50-4 This article mentions the following:
Target validation of current drugs remains the major challenge for target-based drug discovery, especially for agrochem. discovery. The bactericide 0 represents a novel lead structure and has shown potent efficacy against those diseases that are extremely difficult to control, such as rice bacterial leaf blight. However, no detailed target anal. of this bactericide has been reported. Here, we developed a panel of 0-derived probes 1-6, in which a conservative modification (alkyne tag) was introduced to keep the antibacterial activity of 0 and provide functionality for target identification via click chem. With these cell-permeable probes, we were able to discover dihydrolipoamide S-succinyltransferase (DLST) as an unprecedented target in living cells. The probes showed good preference for DLST, especially probe 1, which demonstrated distinct selectivity and reactivity. Also, we reported 0 as the first covalent DLST inhibitor, which has been used to confirm the involvement of DLST in the regulation of energy production In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4Product Details of 180636-50-4).
Methyl 4-fluoro-3-methylbenzoate (cas: 180636-50-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 180636-50-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics