Boc-D-Leu-OMe (cas: 133467-01-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 133467-01-3
Probing the Role of the C-H璺矾璺疧 Hydrogen Bond Stabilized Polypeptide Chain Reversal at the C-terminus of Designed Peptide Helices. Structural Characterization of Three Decapeptides was written by Aravinda, Subrayashastry;Shamala, Narayanaswamy;Bandyopadhyay, Abhishek;Balaram, Padmanabhan. And the article was included in Journal of the American Chemical Society in 2003.Product Details of 133467-01-3 This article mentions the following:
The structural characterization in crystals of three designed decapeptides containing a double D-segment at the C-terminus is described. The crystal structures of the peptides Boc-Leu-Aib-Val-Xaa-Leu-Aib-Val-DAla-DLeu-Aib-OMe, (peptides 2, 3, 4 have Xaa = Gly , DAla , Aib, resp.) have been determined and compared with those reported earlier for peptide 1 (Xaa = Ala) and the all L analog Boc-Leu-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe, which yielded a perfect right-handed 浼?helical structure. Peptides 1 and 2 reveal a right-handed helical segment spanning residues 1 to 7, ending in a Schellman motif with DAla(8) functioning as the terminating residue. Polypeptide chain reversal occurs at residue 9, a novel feature that appears to be the consequence of a C-H璺矾璺疧 hydrogen bond between residue 4 C浼?/sup>H and residue 9 CO groups. The structures of peptides 3 and 4, which lack the pro R hydrogen at the C浼?/sup> atom of residue 4, are dramatically different. Peptide 3 adopts a right-handed helical conformation over the 1 to 7 segment. Residues 8 and 9 adopt 浼?sub>L conformations forming a C-terminus type I’ 灏?turn, corresponding to an incipient left-handed twist of the polypeptide chain. In peptide 4, helix termination occurs at Aib(6), with residues 6 to 9 forming a left-handed helix, resulting in a structure that accommodates direct fusion of two helical segments of opposite twist. Peptides 3 and 4 provide examples of chiral residues occurring in the less favored sense of helical twist; DAla(4) in peptide 3 adopts an 浼?sub>R conformation, while LVal(7) in 4 adopts an 浼?sub>L conformation. The structural comparison of the decapeptides reported here provides evidence for the role of specific C-H璺矾璺疧 hydrogen bonds in stabilizing chain reversals at helix termini, which may be relevant in aligning contiguous helical and strand segments in polypeptide structures. In the experiment, the researchers used many compounds, for example, Boc-D-Leu-OMe (cas: 133467-01-3Product Details of 133467-01-3).
Boc-D-Leu-OMe (cas: 133467-01-3) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 133467-01-3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics