A series of novel HDAC inhibitors with anthraquinone as a cap group was written by Zou, Yefang;Cao, Zhuoxian;Wang, Jie;Chen, Xiaoxue;Chen, Yan-qin;Li, Yan;Liu, Jingzi;Zhao, Yonglong;Wang, Aimin;He, Bin. And the article was included in Chemical & Pharmaceutical Bulletin in 2020.Recommanded Product: 3903-40-0 This article mentions the following:
Although anthraquinone derivatives possess significant antitumor activity, most of them also displayed those side effects like cardiotoxicity, mainly owing to their inhibition of topoisomerase II of DNA repair mechanisms. Our raised design strategy by switching therapeutic target from topoisomerase II to histone deacetylase (HDAC) has been applied to the design of anthraquinone derivatives in current study. Consequently, a series of novel HDAC inhibitors with a tricylic diketone of anthraquinone as a cap group have been synthesized. After screening and evaluation, compounds 4b, 4d, 7b and 7d have displayed the comparable inhibition in enzymic activity and cell proliferation than that of Vorinostat (SAHA). Notably, compound 4b showed certain selectivity of antiproliferative effects on cancer cell lines over non-cancer cell lines. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Recommanded Product: 3903-40-0).
12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 3903-40-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics