Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation was written by Zhao, Xianghua;Yang, Zehui;Cheng, Yuqi;Huang, An;Hu, Fangyuan;Ling, Fei;Zhong, Weihui. And the article was included in Advanced Synthesis & Catalysis in 2022.SDS of cas: 13669-10-8 This article mentions the following:
The iridium/f-diaphos L2 or L9 catalyzed asym. hydrogenation of β-aryl β-keto amides (esters), and β-amino ketones to afford two enantiomers of the desired chiral alcs. was realized with 90%-99% yield and 73%-99% ee. This protocol could be easily conducted on gram scale in the presence of low catalyst loading (up to 9900 TON). Moreover, the hydrogenated products are versatile building blocks for a variety of biol. active mols. and drugs, such as Fluoxetine, Dapoxetine and so on. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8SDS of cas: 13669-10-8).
Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 13669-10-8
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics