Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain “C-region” was written by Walpole, Christopher S. J.;Wrigglesworth, Roger;Bevan, Stuart;Campbell, Elizabeth A.;Dray, Andy;James, Iain F.;Masdin, Kay J.;Perkins, Martin N.;Winter, Janet. And the article was included in Journal of Medicinal Chemistry in 1993.Safety of 12-Methoxy-12-oxododecanoic acid This article mentions the following:
Structural variants of the hydrophobic side chain (C region) of the capsaicin mol. have been incorporated into a series of vanillylamides and vanillylthioureas. These compounds have been tested in an in vitro assay for agonism (45Ca2+ influx into dorsal root ganglia neurons), previously shown to be predictive of analgesic activity. The results of this study have established the requirement for a hydrophobic substituent of limited size (molar refractivity, MR, <55) in order to obtain high potency. Combination of the information about the C-region of the capsaicin mol. with studies of the other parts of the mol. provides a rational basis for the design of compounds of increased potency. In the experiment, the researchers used many compounds, for example, 12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0Safety of 12-Methoxy-12-oxododecanoic acid).
12-Methoxy-12-oxododecanoic acid (cas: 3903-40-0) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Safety of 12-Methoxy-12-oxododecanoic acid
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics