Convenient synthesis of 5-arylidene-2-imino-4-thiazolidinone derivatives using microwave irradiation was written by Sarkis, Manal;Tran, Diem-Ngan;Dasso Lang, Maria Chiara;Garbay, Christiane;Braud, Emmanuelle. And the article was included in Synlett in 2014.Quality Control of 4-Fluorobenzylisothiocyanate This article mentions the following:
A concise approach for the preparation of 5-arylidene-2-imino-4-thiazolidinone derivatives, e.g., I, is described. Structurally diverse amines, isothiocyanates, aldehydes, and chloroacetyl chloride were combined under microwave irradiation to afford new 5-arylidene-2-imino-4-thiazolidinone derivatives The one-pot synthesis involves the in situ formation of a thiourea followed by reaction with chloroacetyl chloride and an aldehyde to generate the target compounds In the experiment, the researchers used many compounds, for example, 4-Fluorobenzylisothiocyanate (cas: 2740-88-7Quality Control of 4-Fluorobenzylisothiocyanate).
4-Fluorobenzylisothiocyanate (cas: 2740-88-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Quality Control of 4-Fluorobenzylisothiocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics