New methods for solid phase peptide synthesis of transition-state analog inhibitors of HIV-1 protease and DPP-IV was written by Piron, Jan;Tourwe, Dirk. And the article was included in Letters in Peptide Science in 1995.SDS of cas: 87694-53-9 This article mentions the following:
A new and stereoselective method to synthesize hydroxyethylamine and hydroxymethylamide peptide bond isosteres is developed. The key step is the addition of 2-trimethylsilylthiazole to α-amino aldehydes, followed by transformation to α-hydroxy-β-amino aldehydes. The stereochem. of the addition can be manipulated by the choice of the nitrogen substitution. The isosteres are easily synthesized via solid-phase peptide synthesis, which rapidly gives the desired pseudopeptides. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9SDS of cas: 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 87694-53-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics